San Marco Vacations from $1,242

Book a Hotel + Flight or Car together to unlock savings

Your San Marco Vacation

Lock in a San Marco vacation package and get set to experience all this lively city has to offer. Consider staying in the neighborhood of San Biagio della Valle, which is great for views, nature and history. You'll want to sightsee during your trip to San Marco. Carve out some time for big-name attractions such as Piazza IV Novembre, Rocca Paolina and Basilica San Pietro. Your ultimate San Marco vacation is a couple of clicks away. Explore airfares, hotels and more on Expedia for an adventure that's tailored to suit your travel style.

The Latest San Marco vacation packages

Price found within the past 48 hours. Click for updated prices.
Borgo Mandoleto

Borgo Mandoleto

3 out of 5
Price was $1,419, price is now $1,242 per person
$1,242
per person
Jul 31 - Aug 5
found 19 hours ago
Roundtrip non-stop flight included
Knoxville (TYS) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG)
9/10 Wonderful! (33 reviews)
Pleasant atmosphere, friendly staff. Noce pool

Reviewed on Jul 1, 2023

Posta Donini 1579 UNA Esperienze

Posta Donini 1579 UNA Esperienze

5 out of 5
Price was $1,688, price is now $1,378 per person
$1,378
per person
Jul 31 - Aug 5
found 19 hours ago
Roundtrip non-stop flight included
Knoxville (TYS) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG)
9.2/10 Wonderful! (255 reviews)
Great grounds, lovely bedroom with character. Very peaceful also

Reviewed on Aug 19, 2025

Nun Assisi Relais Spa Museum

Nun Assisi Relais Spa Museum

5 out of 5
Assisi Historic Center
Price was $2,655, price is now $2,197 per person
$2,197
per person
Jul 31 - Aug 5
found 19 hours ago
Roundtrip non-stop flight included
Knoxville (TYS) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG)
9.8/10 Exceptional! (192 reviews)
Loved it and the restaurant is phenomenal will always come back

Reviewed on May 14, 2026

Locanda Poggioleone

Locanda Poggioleone

3 out of 5
Price was $1,810, price is now $1,512 per person
$1,512
per person
Jul 31 - Aug 5
found 19 hours ago
Roundtrip non-stop flight included
Knoxville (TYS) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG)
9.2/10 Wonderful! (57 reviews)
Lovely country and a peaceful escape. Staff are wonderful. A quick drive into Castiglione del Lago.

Reviewed on Apr 19, 2026

Locanda della Posta - Etruria Collection

Locanda della Posta - Etruria Collection

4 out of 5
Old Town Perugia
Price was $1,516, price is now $1,287 per person
$1,287
per person
Jul 31 - Aug 5
found 19 hours ago
Roundtrip non-stop flight included
Knoxville (TYS) to Perugia San Francesco d'Assisi – Umbria Intl. Airport (PEG)
9.6/10 Exceptional! (199 reviews)
Room was spacious and clean. Breakfast had a lot of variety. Staff was wonderful and location was perfect!

Reviewed on Jun 10, 2026

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San Marco Hotel Deals

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Localita Piazzano, C.P. 6 Cortona AR
$625 nightly
The price is $696 total per night from Jun 24 to Jun 25
$696 total
Jun 24 - Jun 25
Total with taxes and fees
9.8/10 Exceptional! (237 reviews)
"The Villa is not only one of the most beautiful places on earth but also comfortable warm and inviting. The accommodations are gorgeous and the food is magnificent! The staff is a dream~ so kind and personable. I highly recommend as it will be a trip of a lifetime !!!!"

Reviewed on Jun 9, 2026

Villa di Piazzano - Small Luxury Hotel of the World
La Meridiana Bleisure Hotel

La Meridiana Bleisure Hotel

4 out of 5
42 del Discobolo St. Perugia PG
Fully refundableReserve now, pay when you stay
$106 nightly
The price is $123 total per night from Jun 28 to Jun 29
$123 total
Jun 28 - Jun 29
Total with taxes and fees
8.6/10 Excellent! (352 reviews)
"The best hotel and seevices u can ever have. Definitely recommend!!"

Reviewed on Oct 16, 2025

La Meridiana Bleisure Hotel
Hotel Sangallo Palace

Hotel Sangallo Palace

4 out of 5
Via L Masi 9 Perugia PG
Fully refundableReserve now, pay when you stay
$95 nightly
The price is $111 total per night from Jun 19 to Jun 20
$111 total
Jun 19 - Jun 20
Total with taxes and fees
8.8/10 Excellent! (643 reviews)
"We had an excellent stay at hotel Sangallo palace! Location was perfect, the staff were extremely helpful, and the room was clean and spacious!"

Reviewed on Jun 13, 2026

Hotel Sangallo Palace
See all 3,325 properties in San Marco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best San Marco Vacation Packages

San Marco Essential Information

Language
Italian
Currency
Euros
Local Welcome
Ciao
Local Goodbye
Ciao
Closest Airport
Sant Egidio Airport (PEG)
Max Temp Winter
50ºF
Max Temp Summer
85ºF
Top Sights
Cathedral of Saint Lorenzo, Citta della Domenica and Castello di Ramazzano

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Frequently asked questions

How much does a San Marco vacation package cost?
Offering excellent value package deals from $1,242 on Expedia, you'll be thrilled with how little a vacation to San Marco costs! Our packages make travel planning easier and save you more.
What are the cheapest months to go to San Marco?
November, December and January are great times to search for cheap San Marco vacation packages. Traveling in less busy periods means you'll typically find lower prices on hotels and flights.
How many days is enough for San Marco?
The ideal length for your San Marco vacation depends on what you'd like to see and do. Generally, a handful of days to a week will give you enough time to tick off all the leading sights and explore some hidden treasures along the way.
How to find the best San Marco package deals?
Begin your search for a San Marco package deal by entering your travel dates and destination under our "Packages" tab. Then add a few filters, like "Property type" and "Guest rating," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with unbeatable savings. If you don't find the perfect San Marco package deal straight away, simply play around with your dates and search again. Keep in mind that deals are only available for a limited time, so book early and get your San Marco escape off to a flying start.
Is it cheaper to book a San Marco vacation as a package?
Expedia vacation packages are designed to make your money go further. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll generally score a better deal than booking each component individually. And you'll still have the freedom to create a personalized San Marco vacation by choosing your favorite type of stay, airline and car class.
When to book a vacation package to San Marco?
If you've got your San Marco travel dates locked in, book as soon as you can to score some terrific deals. With Expedia, you can typically reserve some flights up to one year in advance. Prefer spur-of-the-moment adventures? Our last-minute deals are perfect for quick escapes.
Does Expedia offer Book Now, Pay Later San Marco vacation packages?
Your San Marco trip is meant to be a relaxing escape from your busy life, not a source of money-related stress. So to give you that extra flexibility, we've teamed up with online lender Affirm to bring you our Book Now, Pay Later vacations. Choose one of our vacation packages with payment plans and split up the cost over 3, 6 or 12 months. Plus, there are no late payment fees or hidden costs to worry about.

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.